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Title: The role of NT-proBNP peptide in the diagnosis and risk assessment in adult patients with syncope


Introduction: syncope is a temporary loss of consciousness, which is the result of global brain hypoperfusion, characterized by rapid onset, short duration, and spontaneous complete resolution.Aim of the study:- analysis of NT-proBNP concentrations in patients with cardiogenic syncope compared to patients with neurogenic syncope.- determination of the threshold values of NT-proBNP to differentiate these groups of patients.- assessment of the impact of serious arrhythmias on value of NT-proBNP.Materials and methods: we studied 100 patients with a history of syncope, in whom, according to ESC guidelines, the final diagnosis was neurogenic (group I) or cardiac syncope (group II).Results: group I - 50 patients (31 F, 19 M) with neurogenic syncope (49 patients vasovagal syndrome) and group II - 50 patients (25 F, 25 M) with cardiogenic syncope (47 of arrhythmias).NT-proBNP was significantly higher in group II in comparison to group I (448.7 ± 212.2 vs. 68.2 ± 64.1, P <0.0001); in the group with VT 526 ± 217 to 225 ± 230 pg / ml in patients without this arrhythmia (p <0.0001), with a third-degree AV block 437 ± 205 compared to 259 ± 246 in those without the disorder (p <0.001).NT-proBNP concentration at 210.5 pg / ml may predict cardiogenic cause of syncope with 98% specificity, 94% sensitivity and 94% negative predictive value.Conclusions:- the concentration of the peptide NT-proBNP of 210.5 pg / ml demonstrated high sensitivity, specificity, and negative predictive value in determining the etiology of syncope.- the concentration of peptide NT-proBNP is higher in patients with syncope, in which there are structural disorders, in comparison to patients without these pathologies.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.


Jadwiga Nessler

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tylko w bibliotece

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Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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Last modified:

Jun 27, 2019

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Jul 17, 2013

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Edition name Date
ZB-118703 Jun 27, 2019


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