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Title:
Evaluation of the progress of retinoblastoma treatment
Author:
Subject:
chemoreduction ; local therapy of retinoblastoma ; retinoblastoma
Abstract:
The aim of the study was to assess the progress in the treatment of retinoblastoma using chemoreduction in conjunction with local therapy as compared to local therapy exclusively. In order to assess the progress in the treatment of retinoblastoma I performed the analysis of the type and quantity of the introduced local treatment, survival, eyeball sparing, histopathological findings, effectiveness of chemoreduction, visual acuity as well as a number of metastases in both groups of children treated with or without chemoreduction. Better treatment results were revealed in the group treated with chemoreduction. The percentage of survived eyeballs was higher and amounted to 36.3% as compared to 28% of survived eyes in the group of children treated without chemoreduction. In the group after chemoreduction a lower number of deaths was noted (only 1 death, i.e., 1.5%) as compared to the group treated without chemoreduction where 13 children died (9,4%). Similarly, fewer metastases were observed in the group treated with chemoreduction. Beneficial effects of chemoreduction were also confirmed by the results of histopathological examinations. Chemotherapy introduced before the decision about the local treatment also caused the beneficial local effect in form of the reduction of the tumour size. The analysis of visual acuity findings showed comparable results in both groups. In conclusio ; n, the attention should be focused on obtained examination results which confirm the high effectiveness of the treatment of retinoblastoma with chemoreduction and its beneficial systemic effects as well as beneficial local effects. The use of chemoreduction constitutes an essential progress in the treatment of retinoblastoma.