Title:

New serotonin receptors’ ligands in group of 8-aminotheophylline derivatives

Author:

Żmudzki, Paweł

Subject:

LCAPs ; theophylline ; serotonin receptors

Abstract:

In the theoretical part of this dissertation were presented the physiological role of 5-HT1A, 5-HT2A and 5-HT7 receptors and examples of their ligands. The known structure affinityrelationships and the published pharmacological models of the ligand-receptor interactions were also discussed. The results ofthe previous research of serotonin receptor ligands in the group of methylxanthines’ derivatives and the structure-activity relationshipin this group of compounds were presented. In the practical part the synthesis of 7-arylpiperazyinylalkyl derivatives of theophylline with differently substituted 8-aminogroup was presented. The structure of the obtained compounds was confirmed with elemental analysis, MS and 1H-NMR. The purity of these compounds was analyzed with UPLC. The final compounds were checked for their serotonin receptor affinity, what led to identification of compounds, which are 5-HT1A, 5-HT2A and 5-HT7 receptor ligands and one mixed ligand of 5-HT1A and 5-HT7 receptors. Basing on the results the structure-activity relationship in this group of compound was analyzed.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmacja

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Pawłowski, Maciej

Date:

2012

Date issued:

2011

Type:

Praca doktorska

Call number:

ZB-116992

Language:

pol

Access rights:

nieograniczony