Title:

The potential antiatherogenic effect of angiotensin 1-7 receptor pharmacological regulation

Author:

Totoń-Żurańska, Justyna

Subject:

atherosclerosis ; angiotensin-(1-7) ; AVE 0991 ; apoE-knockout mice

Abstract:

The working hypothesis was: angiotensin (1-7) agonist, AVE 0991 could ameliorate the development of atherosclerotic lesions in apolipoprotein E (apoE) - knockout mouse (apoE-KO). 50 female 8-week-old apoE–KO mice on C57BL/6J background were studied. Experimental groups received the same diet as control, mixed with: AVE 0991 in a dose of 0,58 mol/kg b.w./day, perindopril in a dose of 0,4 mg//kg b.w./day and with tiorphan in a dose of 2,5 mg//kg b.w./day. A-779 was given in a dose of 3,3 mg/kg b.w, 3 times a week i.p. Measured by “en face” method, the percentage of occupied by Sudan IV – stained surfaces were: 14.6 ± 2.1% in control group, whereas in AVE 0991 treated group 7.63±1.6%, in perindopril group 2.6 ± 0.5%, in tiorphan group 16.7 ± 2.8%, and in A-779 group 19.2 ± 0.6%. All the differences, except tiorphan were statistically significant. Measured by “cross-section” in 8 consecutive sections mean surfaces±SEM, occupied by oil Red - O stained changes were: 91 416 ± 8 357 m2 in control group versus 47 235 ± 7 546 m2 in AVE 0991 – treated group, 37 107 ± 2 824 m2 in perindopril group, 107 599 ± 9 735 m2 in tiorphan group, and 124 201 ± 10 373 m2 in A-779 group. All the differences, except tiorphan were statistically significant. To our knowledge, this is the first report that shows the effect of angiotensin (1-7) receptor agonist: AVE 0991, on atherogenesis in apoE–knockout mice.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Jacek Jawień

Date:

2011

Date issued:

2011

Type:

Praca doktorska

Format:

application/pdf

Call number:

ZB-116997

ControlNumberVIRTUA:

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Language:

pol

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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