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Tytuł: The potential antiatherogenic effect of angiotensin 1-7 receptor pharmacological regulation
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The working hypothesis was: angiotensin (1-7) agonist, AVE 0991 could ameliorate the development of atherosclerotic lesions in apolipoprotein E (apoE) - knockout mouse (apoE-KO). 50 female 8-week-old apoE–KO mice on C57BL/6J background were studied. Experimental groups received the same diet as control, mixed with: AVE 0991 in a dose of 0,58 mol/kg b.w./day, perindopril in a dose of 0,4 mg//kg b.w./day and with tiorphan in a dose of 2,5 mg//kg b.w./day. A-779 was given in a dose of 3,3 mg/kg b.w, 3 times a week i.p. Measured by “en face” method, the percentage of occupied by Sudan IV – stained surfaces were: 14.6 ± 2.1% in control group, whereas in AVE 0991 treated group 7.63±1.6%, in perindopril group 2.6 ± 0.5%, in tiorphan group 16.7 ± 2.8%, and in A-779 group 19.2 ± 0.6%. All the differences, except tiorphan were statistically significant. Measured by “cross-section” in 8 consecutive sections mean surfaces±SEM, occupied by oil Red - O stained changes were: 91 416 ± 8 357 m2 in control group versus 47 235 ± 7 546 m2 in AVE 0991 – treated group, 37 107 ± 2 824 m2 in perindopril group, 107 599 ± 9 735 m2 in tiorphan group, and 124 201 ± 10 373 m2 in A-779 group. All the differences, except tiorphan were statistically significant. To our knowledge, this is the first report that shows the effect of angiotensin (1-7) receptor agonist: AVE 0991, on atherogenesis in apoE–knoc ; kout mice.
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Data ostatniej modyfikacji:
26 cze 2023
Data dodania obiektu:
8 mar 2013
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274
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http://dl.cm-uj.krakow.pl:8080/publication/3469
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| Nazwa wydania | Data |
|---|---|
| ZB-116997 | 26 cze 2023 |
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