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trimester ; reference intervals ; thyroid gland ; thyroid hormones ; pregnancy
Abstract:
Introduction: Abnormalities in mother’s thyroid gland functioning may underline worse child’s psychosomatic and somatic development. By reason of pregnancy specificity, symptoms overlapping, difficulties ininterpretation of tests results, it is justifiable to elaborate TSH, fT3, fT4 normative data for each trimester of pregnancy. Aims:1. Definition of TSH and free thyroid hormone reference intervals for pregnant women in Lesser Poland Voivodeship. 2. Evaluation of changes in thyroid gland’s morphology during pregnancy on the basis of USG image. 3. Attempt of establishing treatment procedure over pregnant woman with thyroid function disorders. 4. Distinction of a group of women with the risk of thyroid function disorders which requires thyreologic assessment during pregnancy. Methods: 1st group consisting of 130 healthy pregnant women and 2nd group consisting of 100 pregnant women with dysfunction of the thyroid gland were selected. TSH, fT3, fT4 and antiTPO serum concentration for every womenin each trimester of pregnancy was evaluated. Results: Based on our study difference in the reference intervals for pregnant and nonpregnant women for TSH and free thyroid hormones was revealed. Very low lower limit of the reference interval for TSH in the Ist of pregnancy should be noticed. In case of fT4 a decline of the reference intervals for each trimester has been noticed. Patients in ; euthyreosis and with an increased level of anti-TPO should be under special control during pregnancy because of increased probability of hypothyroidism.