Analysis of the mechanisms of resistance in nonfermenting rods - Digital Medical Library

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Title: Analysis of the mechanisms of resistance in nonfermenting rods

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Praca doktorska

Abstract:

The aims of this thesis were to study carbapenem and aminoglycoside resistance and to estimate the level of genetic relatedness among selected group of nonfermenting Gram-negative rods represented by clinical strains of Pseudomonas aeruginosa and Acinetobacter baumannii.Studies of carbapenem-resistant isolates of P. aeruginosa (50) and A. baumannii (39) revealed the presence of selected carbapenem and aminoglycoside resistance determinants among respectively 62% and 100% of strains. It was stated that carbapenem resistance among P. aeruginosa and A. baumannii were co-mediated respectively by down regulation of oprD, metalo-β-lactamases and carbapenem-hydrolysing class D β-lactamases – OXA. Whereas aminoglycoside resistance was co-mediated by enzymes that acetylate (AAC - aminoglycoside acetyltransferases) and phosphorylate (APH - aminoglycoside phosphoryltransferases) these antimicrobials. Studies of carbapenem and aminoglycoside resistance determinants revealed their simultaneous occurrence both in P. aeruginosa (30%) and A. baumannii (97,4%) strains. Analysis of genetic relatedness between carbapenem-resistant P. aeruginosa and A. baumannii isolates unveiled high level of differentiation between strains tested. The phenomenon of multiple resistance mechanisms present in P. aeruginosa and A. baumannii isolates make both species major clinical and public health concerns highlighting the need of routine testing including detection of certain determinants of resistance as well as molecular typing studies. Thorough investigations of these issues will enable to decrease the spread of these particularly dangerous pathogens.

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Level of degree:

2 - studia doktoranckie

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Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Farmaceutyczny.

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application/pdf

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oai:dl.cm-uj.krakow.pl:3449

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tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

P. aeruginosa A. baumannii resistance PCR RAPD

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Digital Medical Library > PhD thesis database

Last modified:

Oct 28, 2019

In our library since:

Mar 7, 2013

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4

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4

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http://dl.cm-uj.krakow.pl:8080/publication/3449

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Edition name	Date
ZB-117213	Oct 28, 2019

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