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Title: Defects in some of the antibacterial immunity mechanisms in thepremature newborns as a risk factor of neonatal sepsis

Abstract:

Bacterial sepsis is the first cause of morbidity and mortality inpreterm newborns. The prevalence of neonatal sepsis correlatesinversely with gestational age and birth weight. The main aim of thepresented study was to shed more light on reactions of the innateimmunity in preterm infants born before the 32nd gestational week(GW) or with a birth weight less than 1500g. The data was obtainedduring ex vivo experiments on the venous cord blood of term andpreterm newborns delivered in the University Hospital in Geneva in2009. The premature babies were divided into 2 groups: VLBW andELBW. 20 adult volunteers constituted the control group. Eventually25 term newborns 19 VLBW and 19 ELBW were included into thestudy.The expression levels of TLR2 and TLR4-CD14-MD2complex was the lowest in ELBW and it significantly increased withgestational age. Plasma activity level of soluble MD2 (sMD-2) wassimilar in all newborns and control adults. Gestational agesignificantly directly influenced opsonisation and phagocytosis ofbacteria. Bacterial stimulation of inflammatory response (synthesis ofIL6 and IL 8) in whole blood showed a significantly greaterresponsiveness in term babies than in adults and preterm newborns.The experiments proved that interferon- stimulates pro-inflammatorycytokine synthesis, and upregulates plasma opsonic capacity in ELBWinfants.The presented research showed that key innate immunefunctions of phagocytes are severely impaired in premature newborns,particularly in ELBW. Stimulation with INF reverse impairedfunctions of leukocytes.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

immunologia ; pediatria ; choroby zakaźne

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Ryszard Lauterbach

Date issued:

2011

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:3444

Call number:

ZB-117070

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Mar 7, 2013

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3

Number of object content views in PDF format

3

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/3444

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ZB-117070 May 24, 2021
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