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Title: Markers of inflammation after myocardial infraction
Abstract:
Inflammation plays a fundamental role in the etiopathogenesis of atherosclerosis and in the ethology of acute coronary syndromes. This study was undertaken to assess changes and prognostic value of inflammatory markers measured early after the onset of myocardial infarction i.e. at 10 days and at 10 weeks. A group of 107 patients with a first myocardial infarction was followed up for 18 months. The primary end points were cardiac death, reinfarction or unstable angina pectoris. At 1.5-year follow-up there were 22 end points, 1 cardiac death, 5 reinfarctions, 16 episodes of unstable angina pectoris. At 10 weeks after myocardial infarction the following inflammatory markers were significantly higher in the event group: CRP, ESR at lh and sICAM-1. Multifactorial analysis, logistic regression analysis and Cox's regression model showed that sICAM-1 >270 ng/ml, CRP> 1.83 mg/1, ESR at 1 h > 14 mm at 10 weeks after the infarction were strong independent predictors of cardiovascular events. The measurement of inflammatory markers may be useful m cardiovascular risk assessment in patients after myocardial infarction. Patients with recurrent coronary events had a different profile of inflammatory changes. In these patients between the 10th day and 10th week the decrease in the concentrations of inflammatory markers was smaller than in event-free patients. Persistence of higher levels of i ; nflammatory markers, especially leucocytosis, ESR and sICAM-1 in the event group may indicate prolonged inflammatory activity and endothelial stimulation. The patients with higher levels of inflammatory markers after myocardial infarction may show overreactivity of the immune system.
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Last modified:
Jul 7, 2022
In our library since:
Nov 21, 2012
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25
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0
All available object's versions:
http://dl.cm-uj.krakow.pl:8080/publication/1376
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| Edition name | Date |
|---|---|
| ZB-99798 | Jul 7, 2022 |
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