Obiekt
Tytuł: Diagnostyczne i prognostyczne znaczenie aldehydemii w ostrym zatruciu etanolem
Abstrakt:
Ethanol is oxidized to acetaldehyde by alcohol dehydrogenase (ADH) and this is the main pathway of alcohol oxidizing in social drinkers. Microsomal Ethanol Oxidizing System (MEOS) is induced in ethanol addicted individuals and plays the important additional role in ethanol oxidation in this group. The aldehyde dehydrogenase (AlDH), enzyme oxidizing acetaldehyde to acetic acid, activity does not get changed. This may lead to acetaldehyde cumulation in alcoholic individuals. The aim of the study was to define the usefulness of acetaldehyde concentration measurement in the blood as the marker of alcohol addiction. 53 alcohol addicted and acutely poisoned patients (males) participated in the study. The control group was social drinkers, 43 males, accidentally poisoned with ethanol. Alcohol addiction was diagnosed according to ICD-10 criteria. On admission to the hospital patient’s history was taken and physical examination was performed. Additionally ECG examination was carried out. Blood samples for biochemical analysis (K, Na, glucose, bilirubine, AST, ALT, GGT, CPK, urea, creatinine, iron, protrombin, Ht, Hb, RBC, WBC, Plt) were taken on admission. Blood samples for toxicological analysis were taken on admission, after 4, 8 and 12 hours. Toxicological analysis consisted of measurements of ethanol, acetaldehyde, methanol and acetone concentrations. The ethanol co ; ncentration in blood was measured by enzymatic method (ADH) and acetaldehyde, methanol and acetone concentrations by using headspace gas chromatography. Because of differences of ethanol concentrations, on admission, in two examined groups (alcoholics and social drinkers) the normalization of acetaldehyde results were performed by dividing its concentrations by ethanol concentrations for each sample. The same procedure was carried out for methanol and acetone. Significant faster elimination of ethanol in alcoholic individuals was elicited (β60 = 0.25 for alcoholics and 0.13 for social drinkers). The results of mean acetaldehyde concentrations were higher in alcoholics then social drinkers, but these differences were not statistical significant (except results obtained from blood taken on addmision). There was not significant difference between examined groups in acetaldehyde/ethanol ratio, in each time. These results suggest, that measurement of acetaldehyde concentration in man acutely poisoned with ethanol, do not allow to distinguish alcoholics from social drinkers. Results of classical markers of alcoholism as AST, ALT, GGT activity and MCV were statistical significant higher in alcoholic individuals.
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Data ostatniej modyfikacji:
7 lip 2022
Data dodania obiektu:
21 lis 2012
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http://dl.cm-uj.krakow.pl:8080/publication/1365
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| Nazwa wydania | Data |
|---|---|
| ZB-99565 | 7 lip 2022 |
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