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Title: Investigations on the stability of 2-thioluminal and their methyl derivatives in presence of [beta]-cyclodextrin

Author:

Żuchowski, Grzegorz

Date:

2004

Type:

Praca doktorska

Abstract:

The aim of investigations was to find out the dependence between the position of methyl group and the rate or the hydrolytic degradation reaction in the presence of β-cyclodextrin. The investigated hydrolysis reactions : of 2-thioluminal and its N-methyl and N,N'-dimethyl derivatives were run in the presence of 0%, 0.5%, 1.0% and 1.5% of β-cyclodextrin. There were three main tasks in measurements and calculations. The first was to describe the kinetics of the reactions. The second was to confirm formation of inclusion complexes between the β-cyclodextrin and the investigated compounds, and that was determined by 1H NMR, 13C NMR spectroscopy and molecular modelling (AM1). The last one is to describe reactions by molecular modelling. Kinetic investigations were carried out spectrophotometrically under different conditions of pH, temperature and β-cyclodextrin concentration. Molecular modelling of the investigated reactions was , preformed using semiempirical (PM3) and ab initio (Hartree-Fock. basis 3-21 G) methods.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

chemia ; farmacja

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Bojarski, Jacek Tadeusz

Date issued:

2004

Identifier:

oai:dl.cm-uj.krakow.pl:1362

Call number:

ZB-99546

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

hydrolysis molecular modeling 2-thioliminal [beta]-cyclodextrin

Object collections:

Last modified:

Feb 13, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

17

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1362

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Edition name Date
ZB-99546 Feb 13, 2023

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