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This publication is protected and can be accessed only from certain IPs.

Title: Densitometric quality evaluation of some betaadrenergic blocking agents

Author:

Kwiecień, Anna

Date:

2004

Type:

Praca doktorska

Abstract:

A new chromatographic-densitometric method for the simultaneous identification and quantitation of some chosen betablockers has been developed and used for quantitative determination of atenolol, acébutolol, propranolol and bisoprolol in pharmaceutical preparations. The stability of the most hydrophilic atenolol, less hydrophilic acébutolol and the most lipophilic propranolol has been investigated under the influence of temperature in acid and basic solutions of four concentrations. The chemical structures of the degradation products have been established by comparing Rf values, absorption spectra and ’H NMR. Correlation between kinetic or thermodynamic parameters describing degradation process of chosen betablockers and their polarity has been investigated. It was stated that with increasing polarity (atenolol, acébutolol, propranolol) the stability of these substances increases. Moreover, the problem of degradation of betablockers in solutions of different pH may be important for technology of producing drugs and for their effectiveness and safety of using.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Krzek, Jan

Date issued:

2004

Identifier:

oai:dl.cm-uj.krakow.pl:1351

Call number:

ZB-99182

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

densitometry kinetics thin-layer chromatography drug analysis

Object collections:

Last modified:

Jan 23, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

31

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1351

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Edition name Date
ZB-99182 Jan 23, 2023

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