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Title: Influence of some aroxy-ethyl-amins derivatives on antioxidant system in the human blood and the human placenta

Abstract:

The aim of the study was to investigate aroxyethylamins derivatives influence on antioxidant system of the human blood, human placenta and fetal membranes. Ferric reducing ability of plasma (FRAP), superoxide dismutase (SOD) and catalase (CT) activities in red blood cells and placental homogenates were determined. Antioxidant properties of studying compounds were compared to well known antioxidants: Trolox, Resveratrol and -Carotene. Overall results strongly suggest that: 1/ FRAP values in he blood samples increased more after incubation with -Carotene than with Trolox or Resveratrol; 2/ -Carotene and Trolox increased CT activity whereas Resveratrol increased SOD activity. 3/ 4-orto-methoxyphenylpiperazine derivatives had antioxidant properties. 1 substituent at the phenoxyl group predisposed compounds toinfluence on CT and FRAP. 2 substituent at the same chemical group led to impact of SOD activity. 4/ Derivatives with xanthone structure and amin-butanol groups characterized prooxidative properties. These compounds decreased antioxidant enzymes activities.

Level of degree:

2 - studia doktoranckie

Degree discipline:

biochemia

Degree grantor:

Wydział Farmacji

Promoter:

Marek Stępniewski

Date issued:

2003

Format:

text/html

Identifier:

oai:dl.cm-uj.krakow.pl:1319

Call number:

ZB-98615

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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Last modified:

May 10, 2019

In our library since:

Nov 21, 2012

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All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1319

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ZB-98615 May 10, 2019
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