Object

Title: Selected proinflammatory cytokines in the blood of children with migraine and episodic tension-type headache

Abstract:

The aim: Neurogenic inflammation may contribute to the (max 1400 znak6w) pathogenesis of migraine, but not episodic tension-type headache (ETTH). The aim of this research was to establish whether in children during migraine and ETTH the level of IL-1 beta, IL-6, TNF and soluble TNF receptor type I (sTNFRI) was changed, and whether the level of those cytokines in headache-free period differs between groups with headache and controls. Material: 89 children aged 6-17 years were included ( 16 with migraine with aura, 14 without aura, 31 with ETTH and 28 controls without headaches). Methods: In children with headaches, the blood was sampled in the first hour and in 3 and in 6 hour of the headache, 6 hours after pain termination, in the headachefree period, and in controls under the same conditions. Results: No differences in cytokine levels were detected during headache attack between groups with migraine and ETTH and during headache-free interval between groups of headache and controls. In 12/30 children with migraine the significant increase in IL-6 level was detected in the first hour of attack. The level of IL-1 beta was higher in migraine without aura during headache-free period and in the 1. hour of attack, TNF level was higher in this group 6 hours after pain termination, as compared with migraine with aura. There was significant increase in IL-6 level ; s in 61 children in 3 and 6 hour of headache. Conclusions: The significant mcrease m IL-6 level in several children with migraine in the first hour of the attack may suggest inflammatory pathogenesis of migraine. The significantly lower IL-1 beta and TNF levels in children with migraine with aura may reflect difference in the pathogenesis of both types of the migraine. The increase in IL-6 level in children with longer duration of headache may reflect a stress reaction.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

neurologia ; pediatria

Degree grantor:

Wydział Lekarski

Promoter:

Kaciński, Marek

Date issued:

2004

Identifier:

oai:dl.cm-uj.krakow.pl:1315

Call number:

ZB-100791

Language:

pol

Access rights:

nieograniczony

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Last modified:

Jun 23, 2022

In our library since:

Nov 21, 2012

Number of object content hits:

505

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0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1315

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ZB-100791 Jun 23, 2022
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