Obiekt
Tytuł: Brachytherapy to prevent restenosis after ballon angioplasty in animal model
Abstrakt:
Brachytherapy after angioplasty is an effective technique to avoid this adverse effect. It utilizes radioactive isotopes placed in vessels subjected for radiation. Several experimental and clinical studies showed the efficacy of brachytherapy and established the dose of radiation. However no study was reported so far checking the effects of different dose rates. Therefore the aim of this experiment is to check the effect of different dose rates on neointima proliferation utilizing P32 after PTCA, establish its role on vessel remodelling as well as to examine its safety (thrombosis and vessel injury). A total of 117 porcine arteries were subjected to toxicity, balloon in jury or stenting followed by 20-235 cGy/s of intracoronary radiation (ICR) from a centred P32 source wire to 1 mm beyond lumen surface or a sham ICR procedure. After 4 weeks angiography and IVUS was performed, animals were euthanized and vessels were harvested for histomorphometry. Brachytherapy is an effective method to decrease restenosis after PTCA; No edge effect was observed; Thrombus formation was more frequent after ICR; Thrombosis did not exceed 50% of the vessel lumen and was related to wall injury; Thrombosis did not correlate with dose rate; In the toxicity group and after balloon injury dose rate had a big impact on vessels positive remodelling; Inhibition of neointima proliferation was the main ; effect of brachytherapy in stented vessels; Dose rate up to 235 cGy/s is safe and effective to reduce restenosis after PTCA.
Miejsce wydania:
Stopień studiów:
Dyscyplina:
Instytucja nadająca tytuł:
Promotor:
Data wydania:
Identyfikator:
Sygnatura:
Język:
Prawa dostępu:
Kolekcje, do których przypisany jest obiekt:
Data ostatniej modyfikacji:
8 lis 2023
Data dodania obiektu:
21 lis 2012
Liczba wyświetleń treści obiektu:
389
Liczba wyświetleń treści obiektu w formacie PDF
39
Wszystkie dostępne wersje tego obiektu:
http://dl.cm-uj.krakow.pl:8080/publication/1303
Wyświetl opis w formacie RDF:
Wyświetl opis w formacie OAI-PMH:
| Nazwa wydania | Data |
|---|---|
| ZB-100462 | 8 lis 2023 |
Obiekty
Podobne
Zymek, Pawel
Zasada, Wojciech
Szuścik, Iwona
Wrotniak, Leszek
Raczkowska-Muraszko, Marta
Bogdali, Anna
Strzałka, Anna
