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Title: The influence of platelet glycoprotein IIIa polymorphism on antithrombotic effects of aspirin and clopidogrel in patients with atherosclerosis

Author:

Dyszkiewicz-Korpanty, Anna

Date:

2005

Type:

Praca doktorska

Abstract:

The aim of the dissertation was to analyze the influence of platelet glycoprotein IIIa polymorphism on the antithrombotic effects of aspirin and clopidogrel in patients with atherosclerosis. Thrombin generation, bleeding time and closure time of the PF A-100™ aperture were evaluated in twenty eight patients with coronary heart disease before and after aspirin and clopidogrel intake; six of the 28 patients had co-existing peripheral arterial occlusive disease. Aspirin inhibited thrombin generation and prolonged bleeding time in homozygotes A1. The prolongation of the epinephrine cartridge closure time by aspirin was not influenced by the presence of the polymorphism of platelet glycoprotein IIIa. Clopidogrel inhibited thrombinogenesis and prolonged bleeding time in P1A2 allele carriers only and did not alter the ADP cartridge closure time in either the P1A2 or the P1A1 group. The study results indicate that the choice of antiplatelet therapy could be made on an invidual basis, based on platelet glycoprotein IIIa polymorphism. The P1A2 allele carriers require clopidogrel treatment and aspirin is a drug of choice in the homozygotes A1.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Musiał, Jacek

Date issued:

2005

Identifier:

oai:dl.cm-uj.krakow.pl:1296

Call number:

ZB-100455

Language:

pol

Access rights:

nieograniczony

Subject and keywords:

platelets clopidogrel aspirin polymorphism glycoprotein IIIa

Object collections:

Last modified:

Jun 26, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

291

Number of object content views in PDF format

117

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1296

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Edition name Date
ZB-100455 Jun 26, 2023

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