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Title: Role of melatonin and its precursors l-tryptophan in acute pancreatitis in the rats


Melatonin, a pineal secretory product has received increased attention because of its antioxidative and immunomodulatory properties. Its membrane receptors have been detected in the pancreas and shown to protect the gastric mucosa from acute damage, but the role of melatonin in the protection of the pancreas against acute inflammation is not clear. The aim of this study was to investigate the effects of melatonin and its precursor 1-tryptophan on caerulein-induced pancreatitis (CIP) and on ischemia/reperfusion (I/R)-provoked pancreatitis in rats. In this study we also have evaluated the role of luzindol, nonselective antagonist of melatonin receptor on the course of acute pancreatitis in the rat. Exogenous melatonin or 1-tryptophan attenuates pancreatic damage induced by CIP or by I/R and this effect may be attributable to improving of pancreatic blood flow, the reduction in lipid peroxidation and TNFa release combined with an increase of plasma anti­ inflammatory IL-10 in rats with acute pancreatitis. Administration of luzindol significantly increased the severity of CIP what suggests that endogenous melatonin through its receptors plays an important role in the attenuation of pancreatic damage produced by carulein or I/R.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu trawiennego

Degree grantor:

Wydział Nauk o Zdrowiu


Jaworek, Jolanta

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tylko w bibliotece

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Last modified:

Jan 24, 2023

In our library since:

Nov 21, 2012

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Edition name Date
ZB-100271 Jan 24, 2023


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