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This publication is protected and can be accessed only from certain IPs.
This publication is protected and can be accessed only from certain IPs.

Title: Evaluation of the stability of chosen medicines from quinolone group taking into consideration their interaction with metals

Abstract:

A chromatographic-densitometric method for the simultaneous identification and quantitative determination of ciprofloxacine, norfloxacine and flumequine and their degradation products has been developed and its applicability for quantitative determination of quinolones m pharmaceutical preparations has been checked. The stability of the examined fluoroquinolones has been investigated in acidic and basic solutions in the presence and without chosen metal ions. In the degradation process of ciprofloxacine and norfloxacine one degradation product occurs contrary to flumequine. The investigations revealed that metal ions increase degradation process of ciprofloxacine and norfloxacine to a different degree, that depends on the metal ion, temperature, alkaline or acid reaction and incubation time. The photodegradation of ciprofloxacine m solid phase under the UV radiation in the presence and without metal ions has been investigated and two degradation products appeared during the experiment. It was shown that metal ions increased the degradation process of ciprofloxacine compared to the substance irradiated without metal ions. Based on the obtained results of degradation process of ciprofloxacine and norfloxacine in solutions and during the UV irradiation of ciprofloxacine in solid phase reaction order was established and kinetic parameters k, t0,1 i t0,5 w ; ere calculated. The chemical structures of the degradation products occurring in solutions and in solid phase were established based on chromatographic, spectroscopic and 1 H NMR measurements and the direction of the degradation processes was pointed out. Comparative examinations of antibacterial activity of a chosen ciprofloxacine degradation product occurring in solutions and in solid phase were carried out. It turned out that compared to the ciprofloxacine antibacterial activity, the degradation product is twice less active.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Krzek, Jan

Date issued:

2005

Identifier:

oai:dl.cm-uj.krakow.pl:1270

Call number:

ZB-103089

Language:

pol

Access rights:

tylko w bibliotece

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Last modified:

Apr 19, 2022

In our library since:

Nov 21, 2012

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0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1270

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