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Title:
Role of taurine chloramine in acute inflammatory reaction
Author:
Subject:
taurine bromamine ; taurine ; taurine chloramine ; acute inflammation
Abstract:
Taurine is a sulfonic p-amino acid necessary for proper development of central nervous system as well as function of reproductive and immune system. Taurine haloamines (TauCl and TauBr), synthesized in inflammatory reaction by activated neutrophils and eosinophils, show in vitro considerable immunoregulatory and antibacterial properties. The aim of this work was to investigate these properties of both compounds, which may give reasons for possible therapeutic application of TauBr in acute inflammation. Stability of TauCl and TauBr in acellular environment, at various conditions of pH and temperature has been investigated. Cytotoxicity of both compounds has been studied and maximum non-cytotoxic in vitro and in vivo concentrations determined. An attempt has been made to determine the mechanism of TauCl transport across the cellular membrane. Influence of TauCl and TauBr in vitro on production of cytokines and nitric oxide by inflammatory cells has been studied. Influence of both compounds on acute inflammatory reaction in vivo has been investigated. Both studied taurine derivatives show significant effect in acute inflammatory reaction; TauBr is characterized by weaker anti inflammatory properties and stronger antibacterial action than TauCl. This observation as well as greater stability of TauCl indicates that TauCl is a more promising compound as related to clinical appli ; cation.