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Sierżęga, Marek
2006
Praca doktorska
The aim of this study was to analyse clinical and molecular prognostics factors in resettable pancreatic cancer. One hundred and sixty-five patients underwent pancreatic resections between 1975 and 2004, including 103 (62%) males and 62 (38%) females (mean age 60.4 ±8.7 years). Of 101 tumours subjected to immunohistochemical tests, positive staining was identified for the following proteins: p53 - 71 %; Bcl-2 - 31 %; Bax - 90%; Bel-X - 79%; Bak - 25%. The presence of p53 was associated with poorer differentiation and a higher stage of the primary tumour. Bel-2 protein was related to lower staging, absence of lymph node metastases, and a higher proportion of tumours limited to the pancreas. No statistically significant correlations could be identified for Bel-X, Bax and Bak immunoreactivity and various parameters of the tumour. The median survival was 14.8 months and the 5-year survival was 14.3%. Of all analysed proteins, expression of p53 and Bel-X significantly correlated with poor survival. The following independent negative prognostic factors were identified with the Cox proportional hazards model: moderate or poor differentiation (G2/G3), metastases to regional lymph nodes, the percentage of metastatic lymph nodes > 15%, blood vessels involvement, infiltration of superior mesenteric artery or coeliac trunk, and microscopic or macroscopic residual tumour.
Kraków
2 - studia doktoranckie
onkologia
Wydział Lekarski
Popiela, Tadeusz
2005
oai:dl.cm-uj.krakow.pl:1246
ZB-102669
pol
tylko w bibliotece
Mar 3, 2023
Nov 21, 2012
8
0
http://dl.cm-uj.krakow.pl:8080/publication/1246
RDF
OAI-PMH
Warmus, Janusz
Szurgot, Małgorzata
Walatek, Bogusław
Polak, Jarosław
Wieczorek, Aleksandra
Szastak, Grzegorz
Gacoń, Jacek
Citation style: chicago-author-date iso690-author-date
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