Obiekt
Tytuł: Selected cytokines in fibrosis of the skin and subcutaneous tissue in different types of scleroderma
Abstrakt:
The fundamental component of scleroderma is fibrosis. The aim of the study was to examine interactions between level of selected cytokines measured in serum and supernatant from cultured skin fibroblasts and their correlation with clinical parameters in patients with SSc and LS. The study included: 35 patients with SSc, 41 ones with LS, and a control group. The clinical and biological activity of diseases as well as serum levels of: IL-2, IL-10, IL-12, IL-18, INFγ, TGFβ1 and supernatant levels of: IL-10, IL-12, IL-18 were measured. IL-2 serum level was lower and TGFβ1 serum level was higher in all patients with scleroderma in comparison with the control group. INFγ serum level was lower in all patients with scleroderma in comparison with the control group. IL-12, IL-18 serum level in patients with both types of scleroderma was higher than in the control group. There was lower level of IL- 10, IL- 12, IL-18 in supernatant from cultured fibroblasts taken from patients with systemic scleroderma than in supernatant from control group. We noticed synergic IL-12 and IL-18 increase in both groups of patients. Conclusions: Low serum level of INFγ and high serum level of IL- 12, IL-18 in patients with SSc and LS may be observed because of predominance of inactive form of IL- I 8. Low supernatant level of IL- I O, IL- I 2, IL-18 in patients with SSc may be the result of low INFγ serum le ; vel. Low serum level of INFγ in patients with localized scleroderma may caused by high supernatant level of IL- 10, as well as, low supernatant level of IL-12, which determines lack of biological activity of IL-18 regardless to its high level.
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Data ostatniej modyfikacji:
18 lip 2022
Data dodania obiektu:
21 lis 2012
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http://dl.cm-uj.krakow.pl:8080/publication/1237
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| Nazwa wydania | Data |
|---|---|
| ZB-102293 | 18 lip 2022 |
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Selected cytokines in fibrosis of the skin and subcutaneous tissue in different types of scleroderma
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