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Tytuł: The influence environmental temperature on satiety signals concentration

Abstrakt:

Among peripheral factors which take part in the control of food intake are peptides released in gastrointestinal traci, like cholecystokinin and ghrelin, and hormones synthesized and released in adipose tissue: leptin and adiponectin. lt is known that the amount of the ingested food depends on environmental temperature. Exposition to high ambient temperature stimulates satiety centre and inhibits hunger centre causing a decrease in the food intake. Low ambient temperature, in turn, causes a considerable increase of appetite. The exact mechanism responsible for the changes of the amounts of the ingested food in relation to environmental temperature has not yet been elucidated. The examined group included 20 healthy, young and lean men, who voluntarily agreed to participate in the experiment. Blood was collected to determine cholecystokinin, ghrelin, leptin, adiponectin, glucose, insulin and free fatty acids after 30 minute stay in the resting position in the room at the controlled temperature of +20°c, + 4°C and +30°C. The plasma concentration of glucose and free fatty acid were determined by using enzymatic methods. Measurement of insulin concentration was done by using IRMA kits and the concentrations of CCK and leptin were determined by using RIA kits. The concentration of ghrelin and adiponectin were determined with ELISA kits. The mean value of cholecystokinin decreased sig ; nificantly after 30 minutes exposition to low ambient temperature to 0,558 ± 0,33 pmol/I as compared with 1,104 ± 0,62 pmol/I, the value determined before the test (p<0,05). There were no significant changes in CCK concentration after 30 minute stay in the room at the temperature of +30°C. The mean value of ghrelin was significantly increased after 30 minute exposition to low temperature (129,5 ± 25,7 pg/ml; p<0,0005) and significantly decreased after 30 minute sitting in the room at the temperature of +30°C ( 72, 19 ± 25, 1 pg/ml; p<0,05), as compared with the mean value obtained following 30 minute stay at room temperature ( 89,09 ± 28,3 pg/ml) . The mean value of leptin concentration following exposition to low temperature was significantly tower (4,65 ± 3,22 ng/ml; p<0,005) as compared to the values before the exposition (6,36 ± 3,50 ng/ml). The elevated temperature did not influence significantly the concentration of leptin. Thirty minutes exposition to low and elevated temperatures did not produce any significant changes in adiponectin concentration. lt has been concluded on the basis of the results obtained that there is interdependence between the changes in the concentration of CCK, ghrelin and leptin and the changes of the ambient temperature. In the case of adiponectin concentration such interdependence was not found.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

biochemia ; fizjologia

Instytucja nadająca tytuł:

Wydział Lekarski

Promotor:

Sztefko, Krystyna

Data wydania:

2005

Identyfikator:

oai:dl.cm-uj.krakow.pl:1230

Sygnatura:

ZB-102166

Język:

pol

Prawa dostępu:

tylko w bibliotece

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Data ostatniej modyfikacji:

18 lip 2022

Data dodania obiektu:

21 lis 2012

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