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Title: Factors affecting haematopoietic recovery in patients after autologous stem cell transplantation
Abstract:
The aims of retrospective study were to evaluate early and late haematopoietic recovery after HDT+autoHSCT in two groups of patients according to diagnosis of acute leukemia (AML. ALL) - Group I and lymphoproliferative disease (NHL. HD. MM) - Group II. establish influence of graft parameters, therapy preceding HDT+autoHSCT and G-CSF treatment after transplantation on haematopoietic recovery, assess of frequency, type and severity of neutropenic infections in both groups of patients, compare immune reconstitution based on lymphocyte subpopulations after transplant in Groups: I and II. analyze graft parameters connected with early relapse occurrence. 143 patients with 154 transplants were included. In acute leukaemia patients short term haematological recovery was significantly slower and long term haematopoietic values were significantly lower than in the other patients. Results of multivariate analysis confirmed the value of stem cell source and dose of CD34+ as factors associated with both - short and long term engraftment. The shortest leukocyte and platelet recovery period was observed in patients treated with G-CSF early after transplant in both study groups. There were no differences in infections and immune recovery in both groups. In patients with lymphoproliferative disorders, when the stem cell source was peripheral blood - the number of mononuclear ceils in the graft ; was significantly higher in patients with relapse of the disease early after HDT.
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Last modified:
Feb 4, 2023
In our library since:
Nov 21, 2012
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3
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http://dl.cm-uj.krakow.pl:8080/publication/1227
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| Edition name | Date |
|---|---|
| ZB-102163 | Feb 4, 2023 |
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