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Title: Blood pressure, arteria! stiffness and longevity : the arterial pulse wave as a marker of arteria! compliance changes in the centenarians


Introduction: The aim of study was to estimate blood pressure and arterial stiffness of centenarians and their offspring. Methods: Investigation was carried out within the project of Committee for Scientific Research: "Genetic and environmental factors oflongevity". We examined: 59 centenarians, 51 of centenarians' off spring and 50 controls. Blood pressure was estimated from the average value of 3 measurements, with sphygmomanometer on the shoulder. Arterial stiffness was estimated by pulse wave analysis. Pressure waveforms were recorded from the radial artery and the waveform data were then processed by SphygmoCor radial/aortic transform software module to produce the estimated aortic pressure waveform. Results: The centenarians' offspring had the lowest values of pulse pressure'. Arteria! stiffness is comparable in three examined groups. There was a tendency to the highest values of SBP and SBPc in the control subjects but in the centenarians there was a tendency to the lowest values of DBP and DB Pe. HT was the most common in the controls but ISH in the centenarians. Hypertensive centenarians had stiffer arteries. Conclusions: Arteria! stiffness of centenarians is comparable to that observed in younger groups, which is probably consequence of delaying of arterial stiffening with advanced age or excluding subjects with less com pliant arteries. Centenarians' off spring h ; ave less stiff arteries and they rarely have hypertension in comparison to agematched controls, which is probably a result of influence of hereditary factors. There is a correlation between arteria! stiffness and blood pressure level in all three grouos.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

geriatria ; fizjologia

Degree grantor:

Wydział Lekarski


Grodzicki, Tomasz

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tylko w bibliotece

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Last modified:

Apr 19, 2022

In our library since:

Nov 21, 2012

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Edition name Date
ZB-102141 Apr 19, 2022


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