Obiekt
Tytuł: Participation of endothelial growth factors, heme oxygenase and Jagged/Notch proteins in differentiation of endothelial cells
Abstrakt:
Angiogenesis is the formation of new blood vessels from pre-existing ones. To the most important factors deciding about the formation of new capillary belong: growth factors, cytokines and cell-to-matrix interactions (integrins), or cell-to-cell adhesive interaction (VE-cadherins, cathenins, endoglins, ephrins and theirs receptors, Jagged/Notch receptors). There is growing evidence for the role of heme oxygenase-1 in the process of angiogenesis. Some studies demonstrated that induction of HO-1 enhance re-endothelization of the injured vessels, and also protect the newly formed endothelial cells from undergoing apoptosis, suppress the proinflammatory phenotype and inhibit smooth muscle cell proliferation. The aim of the study was to examine the influence of growth factors (VEGF-A16s, bFGF), HO-1 on endothelial cell differentiation and on proangiogenic activity of these cells in the model of "tubulogenesis" These results support that HO-I is closely related with angiogenesis inducted by VEGF-A. lt has been suggested that bFGF could exert an influence on angiogenesis through enhancing VEGF-A signalling. It was shown that NO plays an essential role with the cooperation of examined factors in created new vessels. It has been demonstrated that HO-1, like bFGF, but not NO or VEGF-A promotes development and maturation of new capillaries network (which is connected with inhibition o ; f Jagged/Notch gene expression).
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biochemias ; biologia molekularna
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Data ostatniej modyfikacji:
18 lip 2022
Data dodania obiektu:
21 lis 2012
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http://dl.cm-uj.krakow.pl:8080/publication/1202
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| Nazwa wydania | Data |
|---|---|
| ZB-101741 | 18 lip 2022 |
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