Title:

Vitamin C concentration during hemodialysis

Author:

Janusz-Grzybowska, Eve

Subject:

erythropoietin ; vitamin C ; hyporesponsiveness to rHuEPO ; oxidative stress ; hemodialysis

Abstract:

In the first stage of the study, 112 hemodialysis patients and 23 healthy control subjects were qualified. During this oneyear study period, observed were significant low concentrations of vitamin C in the hemodialysis patient group in comparison to the control group. During HD, serum concentration of vitamin C decreased about 45 %. During the second stage of the study, 68 hemodialysis patients were qualified for vitamin C supplementation. After the supplementation period, vitamin C concentration levels significantly increased statistically, returning to similar baseline values during the next 2 months. Statistically significant negative correlation was observed between the increase in vitamin C concentration and the degree of creatinine removal during hemodialysis (et/co). Non-parametric tests showed statistically significant increase (p< 0,00001) of hemoglobin concentration and hematocrit value and statistically significant differences (p<0,00001) in erythropoietin doses during the supplementation cycle, 2 and 4 months after its termination. Dosage of rHuEPO decreased from 3000 U/week/patient to 2000 U/week/patient after the vitamin C supplementation cycle, 2 and 4 months after its termination.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

nefrologia

Degree grantor:

Wydział Lekarski

Promoter:

Sułowicz, Władysław

Date:

2005

Date issued:

2005

Type:

Praca doktorska

Call number:

ZB-101293

Language:

pol

Access rights:

nieograniczony