Title:

Conformational studies of potent ligands of 5-HT1A receptor using 2D NMR techniques

Author:

Żylewski, Marek

Subject:

2D NMR ; NOESY ; long-chained arylpiperazines ; conformation

Abstract:

Analysis of 2D NOESY spectra of various arylpiperazines containing flexible 4-carbon chain showed that small changes in the structure can express in large changes in conformation. Also protonation of the piperazine moiety and change of the solvent can lead to conformation's change. It has been found that arylpiperazines can exist in solution in two different types of conformations. First is, maximally extended conformation, similar to antiperiplanar conformation of butane, in which there wasn't observed any NOE interactions between protons of the two ending methylene groups. The second, which was more often observed, is characterised by strong NOE interactions between all protons in alkyl chain. Such set of signals indicate that these protons have to be much closer in space than it can be achieved in extended conformation. Therefore “kinked” or folded conformation, which is closed to synclinal conformation of butane, has been proposed.

Level of degree:

2 - studia doktoranckie

Degree discipline:

chemia ; farmakologia

Degree grantor:

Wydział Lekarski

Promoter:

Marek Cegła

Date issued:

2005

Type:

Praca doktorska

Format:

application/pdf

Call number:

ZB-101290

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Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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