Conformational studies of potent ligands of 5-HT1A receptor using 2D NMR techniques - Digital Medical Library

Skip to main menu
Skip to search engine
Skip to content
Skip to footer

Download

Description
Information

Title: Conformational studies of potent ligands of 5-HT1A receptor using 2D NMR techniques

Author:

Żylewski, Marek

Date:

Type:

Praca doktorska

Abstract:

Analysis of 2D NOESY spectra of various arylpiperazines containing flexible 4-carbon chain showed that small changes in the structure can express in large changes in conformation. Also protonation of the piperazine moiety and change of the solvent can lead to conformation's change. It has been found that arylpiperazines can exist in solution in two different types of conformations. First is, maximally extended conformation, similar to antiperiplanar conformation of butane, in which there wasn't observed any NOE interactions between protons of the two ending methylene groups. The second, which was more often observed, is characterised by strong NOE interactions between all protons in alkyl chain. Such set of signals indicate that these protons have to be much closer in space than it can be achieved in extended conformation. Therefore “kinked” or folded conformation, which is closed to synclinal conformation of butane, has been proposed.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

chemia ; farmakologia

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:1181

Call number:

Language:

Access rights:

Subject and keywords:

conformation 2D NMR NOESY long-chained arylpiperazines

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Jun 26, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

3 754

Number of object content views in PDF format

85

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1181

Show description in RDF format:

Show description in OAI-PMH format:

Edition name	Date
ZB-101290	Jun 26, 2023

Objects

Similar

Conformational studies of potent ligands of 5-HT1A receptor using 2D NMR techniques

Żylewski, Marek

2005

Praca doktorska

Analysis of interactions between ligands and 5-HT1A and 5-HT7 serotonin receptors using molecular modeling methods

Kołaczkowski, Marcin

2007

Praca doktorska

More

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

https://bm.cm.uj.edu.pl/en/main-page/

This page uses 'cookies'. More information