Conformational studies of potent ligands of 5-HT1A receptor using 2D NMR techniques - Digital Medical Library

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Title: Conformational studies of potent ligands of 5-HT1A receptor using 2D NMR techniques

Author:

Żylewski, Marek

Date:

Type:

Praca doktorska

Abstract:

Analysis of 2D NOESY spectra of various arylpiperazines containing flexible 4-carbon chain showed that small changes in the structure can express in large changes in conformation. Also protonation of the piperazine moiety and change of the solvent can lead to conformation's change. It has been found that arylpiperazines can exist in solution in two different types of conformations. First is, maximally extended conformation, similar to antiperiplanar conformation of butane, in which there wasn't observed any NOE interactions between protons of the two ending methylene groups. The second, which was more often observed, is characterised by strong NOE interactions between all protons in alkyl chain. Such set of signals indicate that these protons have to be much closer in space than it can be achieved in extended conformation. Therefore “kinked” or folded conformation, which is closed to synclinal conformation of butane, has been proposed.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

chemia ; farmakologia

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:1181

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Subject and keywords:

conformation 2D NMR NOESY long-chained arylpiperazines

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Nov 24, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

3 894

Number of object content views in PDF format

99

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1181

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Edition name	Date
ZB-101290	Nov 24, 2023

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