Title:

Application of the TLC method in the studies on the lipophilicity of the selected groups of compounds

Author:

Kępczyńska, Elżbieta

Subject:

logP ; lipophilicity ; RP-TLC method

Abstract:

The RM0 parameter values of N-alkyl derivatives of 1,2,3,4-tetrahydroisoquinoline, N-(2-ethylbutyryl)-N’-substituted derivatives of biuret, derivatives of barbituric acid and of 2-thiohydantoine were determined by means of reversed-phase thin-layer chromatography. Methanol was used as an organic modifier. The obtained values of chromatographic parameter of the lipophilicity, RM0, were analyzed on the basis of the compound structure. The length of carbon chain, the kind of substituent and its position in the ring, the substituent polarity and a possible electron influence were taken into consideration. In the next step, the RM0 parameter was correlated with lipophilicity parameters obtained by other methods, including computational one (log PPallas, log PCAChe, and, for some compounds, with log kIAM – the retention parameter obtained by HPLC chromatography using the immobilized artificial membrane). The linear relationships with the satisfactory correlation coefficients were received. The RM0 values of some compounds were compared to the biological data available in the literature and to other parameters. In many cases the linear correlations between the parameters were found.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Bojarski, Jacek Tadeusz

Date:

2005

Date issued:

2005

Type:

Praca doktorska

Call number:

ZB-101289

Language:

pol

Access rights:

nieograniczony