Title: The usefulness of cytokines blood serum level in patients with acute pancreatitis


The subject of the study were 103 patients with acute pancreatitis (AP). There were 57 patients with biliary and 46 patients with post­ alcoholic. Patients were divided into two groups; edematous pancreatitis (84 patients) and necrotizing (19 patients). Samples of blood from peripheral vein were obtained at 1, 3, 5 and 7th day of hospital stay for assessment of interleukins. Interleukins were assessed by ELISA method using Biosource Europe S.A. kit. The aims of the study were: to evaluate the changes of interleukin levels in the different etiological forms of pancreatitis - biliary and post-alcoholic, to assess which interleukin has the h ighest c orrelation w ith e tiology and severity of the disease, to follow the levels of different interleukins after papillotomy in biliary pancreatitis and to assess whether interleukin-8 may be a marker of necrosis. Important differences in the level of interleukin-6 were observed form the first day of hospitalization and during following days between edematous and necrotizing pancreatitis. Similar differences were observed in levels of interleukin-8 but from 3rd day on and interleukin-10 in the 1st and 5th day. Important differences between biliary and post-alcoholic pancratitis were noticed in the levels of interleukin-2 throughout the study and interleukin-12 in the 1st and 3rd day. Early papillotomy caused significant decrease mean leve ; ls of interleukin 1, 2 and 10. Statistical significance of the difference in the interleukin-8 level between edematous and necrotizing form increased form the 3rd day, and on which may point to the value of it as a marker necrosis. Levels of interleukin-6 and interleukin-10 correlated well with severity of the disease measured by APACHE II scale. Similar observations were made in case of Trapnell’s classification.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu trawiennego

Degree grantor:

Wydział Lekarski


Karcz, Danuta

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Jun 26, 2023

In our library since:

Nov 21, 2012

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Edition name Date
ZB-101119 Jun 26, 2023


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