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Title: Thrombin generation ex vivo in patients with the venous thromboembolic disease and the persistent atrial fibrillation on long term oral anticoagulation
Abstract:
We enrolled 35 patients with a history of venous thromboembolism treated with acenocoumarol (stable INR values -2.0-3.0), normal Creactive protein levels, and 20 patients with atrial fibrillation. The control group included 35 healthy subjects. Laboratory evaluation: aPTT, activity of factor II, VII, IX, X, protein C and S levels, bleeding time (BT), levels of thrombin-antithrombin (TAT) complexes in blood samples taken every 30 seconds at the site of microvascular injury. We tested all patients with point mutation in coagulation factor V Leiden, and prothrombin 20210a. We have found that in persons treated with acenocoumarol there is a remarkable decrease of FII, FVII, FIX, FX activity and protein C and free protein S concentration in comparison with the healthy control. We have shown the negative correlation between this parameters and INR value. We have found no significant correlation between INR and the parameters of the thrombin generation such as TATmax and TATrate. In individuals treated with acenocoumarol the rise in TAT concentration taken from the curves of thrombin generation is significantly lower than in the healthy control. This parameter wasstrongly correlated with the activity of protein C. There was a significant increase of FVIII activity in individuals treated with anticoagulant but we found no correlation between FVIII activity and the time of therapy ; duration. There was no correlation found between the thrombin generation in the site of vascular injury and the time of therapy. Neither the heterozygous Factor V Leiden presence in the individuals treated and the healthy control, nor the next six- month therapy with acenocoumarol shown any influence on the thrombin generation kinetics.
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hematologia ; choroby układu krążenia
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Last modified:
Jul 7, 2022
In our library since:
Nov 21, 2012
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14
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http://dl.cm-uj.krakow.pl:8080/publication/1176
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| Edition name | Date |
|---|---|
| ZB-101025 | Jul 7, 2022 |
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