The effect of polymorphisms of the beta2-adrenergic receptor on the regulation of pulmonary function in patients with bronchial asthma and allergic rhinitis
spirometry ; beta2-adrenoreceptor ; allergic rhinitis ; asthma ; genetic polymorphism
The objective was to investigate the effect of B2 adrenoreceptor polymorphisms Arg16Gly and Gln27Glu on diagnosis of asthma and allergic rhinitis, as well as determination of the relationship between these polymorphisms and pulmonary function, total IgE level and the clinical presentation of the disease. The study group included 142 atients with asthma and/or allergic rhinitis and in 62 healthy subjects. The identification of the polymorphisms was carried out with the RFLP method. No differences in the distribution of polymorphisms were observed between the study group and the control. The studied polymorphisms were in linkage disequilibrium, therefore their effects should be evaluated collectively. In functional tests of the respiratory system the presence of Glyl6/Glu27 diplotype was associated with higher spirometry values in men and lower spiromety values in women, as the Glu27 allel presence. No relationship was observed between the two polymorphisms and total IgE level in the study group. Nocturnal dyspnoea was less frequent in patients with the Gln27 allele and more frequent in patients with Glyl6/Glu27 diplotype. Conclusions: The two analysed polimorphisms are not considered as a major cause ofbronchial asthma and allergic rhinitis. The Argl6Gly and Gln27Glu P2-adrenoreceptor polymorphisms are in linkage disequilibrium and their functional effects depend on thei ; r interaction. These polymorphisms can influence the function of pulmonary system. This effect significantly differs between men and women possibly indicating the effect of sexual hormones on genetic expresion and regulation of pulmonary function.