Object

Title: The effect of polymorphisms of the beta2-adrenergic receptor on the regulation of pulmonary function in patients with bronchial asthma and allergic rhinitis

Abstract:

The objective was to investigate the effect of B2 adrenoreceptor polymorphisms Arg16Gly and Gln27Glu on diagnosis of asthma and allergic rhinitis, as well as determination of the relationship between these polymorphisms and pulmonary function, total IgE level and the clinical presentation of the disease. The study group included 142 atients with asthma and/or allergic rhinitis and in 62 healthy subjects. The identification of the polymorphisms was carried out with the RFLP method. No differences in the distribution of polymorphisms were observed between the study group and the control. The studied polymorphisms were in linkage disequilibrium, therefore their effects should be evaluated collectively. In functional tests of the respiratory system the presence of Glyl6/Glu27 diplotype was associated with higher spirometry values in men and lower spiromety values in women, as the Glu27 allel presence. No relationship was observed between the two polymorphisms and total IgE level in the study group. Nocturnal dyspnoea was less frequent in patients with the Gln27 allele and more frequent in patients with Glyl6/Glu27 diplotype. Conclusions: The two analysed polimorphisms are not considered as a major cause ofbronchial asthma and allergic rhinitis. The Argl6Gly and Gln27Glu P2-adrenoreceptor polymorphisms are in linkage disequilibrium and their functional effects depend on thei ; r interaction. These polymorphisms can influence the function of pulmonary system. This effect significantly differs between men and women possibly indicating the effect of sexual hormones on genetic expresion and regulation of pulmonary function.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

genetyka ; alergologia

Degree grantor:

Wydział Lekarski

Promoter:

Adamek-Guzik, Teresa

Date issued:

2004

Identifier:

oai:dl.cm-uj.krakow.pl:1175

Call number:

ZB-101024

Language:

pol

Access rights:

nieograniczony

Object collections:

Last modified:

Jul 7, 2022

In our library since:

Nov 21, 2012

Number of object content hits:

336

Number of object content views in PDF format

10

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1175

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-101024 Jul 7, 2022
×

Citation

Citation style:

This page uses 'cookies'. More information