Mechanisms of negative regulation of the immune response in experimental allergic encephalomyelitis (EAE) - Digital Medical Library

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Title: Mechanisms of negative regulation of the immune response in experimental allergic encephalomyelitis (EAE)

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Type:

Praca doktorska

Abstract:

Presented work describes a new method of skin induced tolerance via epicutaneous (e.c.) immunization. The aim of this procedure was to delay onset of EAE and reduce its severity. Employing B10.PL mice (mice that develop chronic form of EAE) it was shown that e. c. application of myelin basic protein (MBP) before induction of EAE delayed onset of EAE and reduced disease severity by 50-70% when compared to positive control. The optimal dose of e. c. applied MBP that significantly ameliorates course of a disease is between 0,1-1 mg. Skin induced tolerance is mediated by Tαβ CD4+ CD8+ double positive cells whereas Tγδ and NK-T cells are not involved in this process. Both in vivo and in vitro studies showed that skin induced suppression is antigen non-specific. Epicutaneously induced T suppressor cells (Ts) inhibit inflammatory response via released TGF- β, while IL-4, IL- 10 and IL-13 do not play a crucial role in the observed suppression.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

Degree grantor:

Wydział Lekarski

Promoter:

Szczepanik, Marian

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:1171

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Subject and keywords:

tolerance cytokines experimental allergic encephalomyelitis multiple sclerosis T suppressor cells

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Nov 8, 2023

In our library since:

Nov 21, 2012

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616

Number of object content views in PDF format

46

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1171

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Edition name	Date
ZB-100898	Nov 8, 2023

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