Advanced search ?

Object

Download

Title: Experimental evaluation of endothelial function in spontaneous hypertension

Author:

Jopek, Andrzej

Date:

2007

Type:

Praca doktorska

Abstract:

The endothelial dysfunction seem to be responsible for occurrence of many diseases of the circulatory system. In the hereby elaboration an effort was undertaken to work out a evaluation method of a degree of the endothelial dysfunction in conditions of the oxidative stress caused by the activation of oxidase NAD(P)H. The first part of research was carried out on isolated aortas of control rats (WKY) and rats with idiopathic hypertension (SHR). The second part was carried out on arteries and veins obtained from 160 patients after the surgical procedure of coronary arteries bridging. The dysfunction degree of the endothelium was evaluated by comparison of vasomotor answers of vessels to NADPH and acetylocholine by a technique of the organ bath. There was performed for the same vessels measurement of O2- production by the chemiluminescence. It was proved that at SHR production of O2- is higher than during control, and the main source of O2- is oxidase NAD(P)H. There were observed contrary answers of vessels after NADPH: contractions at SHR (depended on O2- production) and relaxations at WKY (depended on NO and). Similar observations were proved in human vessels - aortas of SHR behaved as human vessels with endothelial dysfunction. In the human vessels the endothelial dysfunction degree correlates with production of O2- and a number of atheromatosis risk factors.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Korbut, Ryszard

Date issued:

2007

Identifier:

oai:dl.cm-uj.krakow.pl:1149

Call number:

ZB-105983

Language:

pol

Access rights:

nieograniczony

Subject and keywords:

NAD(P)H oxidase endothelial dysfunction

Object collections:

Last modified:

Jun 26, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

417

Number of object content views in PDF format

119

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1149

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-105983 Jun 26, 2023

Objects

Similar

Experimental evaluation of endothelial function in spontaneous hypertension

Jopek, Andrzej

2007
Praca doktorska

Relationship between selected polymorphisms of gene encoding p22phox subunit of the NADPH oxidase and endothelial function in patients with type 2 diabetes

Osmenda, Grzegorz

2007
Praca doktorska

Role of superoxide in the pathogenesis of abdominal aortic aneurysms

Guzik, Bartłomiej

2006
Praca doktorska

Some vascular effects of hormones contributing to the regulation of appetite

Kawczyńska-Dróżdż, Agnieszka

2009
Praca doktorska

Selected aspects of endothelial dysfunction in patients with type 2 diabetes

Waluś-Miarka, Małgorzata

2008
Praca doktorska

Prognostic value of endothelial function noninvasive assessment in patients with acute coronary syndrome nonobstructive coronary angiography

Depukat, Rafał

2013
Praca doktorska

Influence of autoimmunity on endothelial dysfunction and atherosclerosis development in young patients with coronary artery disease and in systemic lupus erythematosus patients

Mazurek, Adam

2020
Praca doktorska

MRI - based in vivo assessment of endothelial function in murine models of cardiovascular diseases

Bar, Anna

2019
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information