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Tytuł: Importance of sulfane sulfur and S-thiolation reactions for modulation of biological activity of thiols
Abstrakt:
It has been shown that biologica! activity of thiols is modulated by sulfane sulfurcontaining compounds, and that diallyl disulfide (DADS) can be a valuable source of sulfane sulfur for liver cells. DADS can exhibit efficient protective action in norma! liver cells of Ehrlich ascites tumor-bearing animals, however, it is completely ineffective in changing amounts of sulfane sulfur in Ehrlich ascites tumor cells. Moreover, DADS inhibits [3H]-thymidine incorporation in human hepatoblastoma (HepG2) cell culture. This effect is transient and can result from the formation of unstable hydropersulfides. My studies have also indicated that biological activity of thiols is modulated by Sthiolation and that activation of y-glutamyl transpeptidase (yGT) induces prooxidative conditions m HepG2 cells, which leads to enhancement of S-thiolation by Cys, and Cys-Gly. Blockade of yGT activity by acivicin leads to more reductive conditions and lowers S thiolation by Cys and Cys-Gly. The obtained results confirm that S-thiolation reactions can fulfill the role of a link in regulatory processes and demonstrate an exceptional biologica! role of yGT connected with formation of reactive oxygen species and S-thiolation. In the Iivers of Ehrlich ascites tumor-bearing mice, disruption of thiol homeostasis was connected with an increase in S-cysteinylation. In the livers of ; healthy mice intraperitoneal injection of glutathione disulfide augmented of thiol-disulfide exchange, what was manifested by increased S-glutathionylation.
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Data ostatniej modyfikacji:
24 lut 2023
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21 lis 2012
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http://dl.cm-uj.krakow.pl:8080/publication/1119
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| Nazwa wydania | Data |
|---|---|
| ZB-105467 | 24 lut 2023 |
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