This publication is protected and can be accessed only from certain IPs.
This publication is protected and can be accessed only from certain IPs.

Title: Importance of sulfane sulfur and S-thiolation reactions for modulation of biological activity of thiols


It has been shown that biologica! activity of thiols is modulated by sulfane sulfurcontaining compounds, and that diallyl disulfide (DADS) can be a valuable source of sulfane sulfur for liver cells. DADS can exhibit efficient protective action in norma! liver cells of Ehrlich ascites tumor-bearing animals, however, it is completely ineffective in changing amounts of sulfane sulfur in Ehrlich ascites tumor cells. Moreover, DADS inhibits [3H]-thymidine incorporation in human hepatoblastoma (HepG2) cell culture. This effect is transient and can result from the formation of unstable hydropersulfides. My studies have also indicated that biological activity of thiols is modulated by Sthiolation and that activation of y-glutamyl transpeptidase (yGT) induces prooxidative conditions m HepG2 cells, which leads to enhancement of S-thiolation by Cys, and Cys-Gly. Blockade of yGT activity by acivicin leads to more reductive conditions and lowers S thiolation by Cys and Cys-Gly. The obtained results confirm that S-thiolation reactions can fulfill the role of a link in regulatory processes and demonstrate an exceptional biologica! role of yGT connected with formation of reactive oxygen species and S-thiolation. In the Iivers of Ehrlich ascites tumor-bearing mice, disruption of thiol homeostasis was connected with an increase in S-cysteinylation. In the livers of ; healthy mice intraperitoneal injection of glutathione disulfide augmented of thiol-disulfide exchange, what was manifested by increased S-glutathionylation.

Place of publishing:


Level of degree:

2 - studia doktoranckie

Degree discipline:


Degree grantor:

Wydział Farmaceutyczny


Włodek, Lidia

Date issued:




Call number:




Access rights:

tylko w bibliotece

Object collections:

Last modified:

Feb 24, 2023

In our library since:

Nov 21, 2012

Number of object content hits:


Number of object content views in PDF format


All available object's versions:


Show description in RDF format:


Show description in OAI-PMH format:


Edition name Date
ZB-105467 Feb 24, 2023


Citation style:

This page uses 'cookies'. More information