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Tytuł: The influence of meglumine on the pharmaceutical availability of drugs from pellets
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The aim of this study was application of meglumine as a carrier in solid dispersions pellets containing poorly water soluble drugs. Three drugs were selected as a model: ketoprofen, piroxicam, indomethacin. The melting method and spray-drying method were used to prepare solid dispersions. The properties of meglumine solid dispersions were depended on the method of preparation, the drug/meglumine ratio and properties of the drug. It was found, that melting method was appropriate to obtain solid dispersions of good quality for all drugs. The spray–drying method was suitable for preparation piroxicam and indomethacin meglumine solid dispersions. The best results were obtained for ketoprofen solid dispersions: (1+0.5), (1+1) prepared by melting method and for spray-dried indomethacin solid dispersions (1+0.5), (1+0.25). Three kinds of pellets were prepared by extrusion/spheronisation: containing the drug alone, solid dispersion or physical mixture. The pellets formulation was based on the results of rheological behaviour of wet powder mass which was assessed by using the compresso-rheometer. The present work has demonstrated the improvement of rheological properties of mass for extrusion in the presence of meglumine. Formulations composed of microcrystalline cellulose-lactose-meglumine in the ratio (7+3+0.4) and (7+3+0.5) showed the best rheological properties. Pellets prepared fro ; m different kinds of excipients were characterised in terms of shape, porosity, size distribution and dissolution behaviour. Dissolution studies of solid dispersion pellets showed enhancement in the dissolution rate of drugs. The increase in the amount of released drug from solid dispersions pellets was greater than from the pellets containing drug alone. After 20 minutes almost total amount of ketoprofen and indomethacin was dissolved from pellets. In the case of piroxicam the best results were obtained by using the layering method in pellets formulation. The amount of piroxicam dissolved from these pellets was two times greater than from pellets obtained by extrusion spheronisation. The dissolution profiles of drugs from pellets were unchanged after one year storage.
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Data ostatniej modyfikacji:
19 lip 2022
Data dodania obiektu:
21 lis 2012
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http://dl.cm-uj.krakow.pl:8080/publication/1118
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| Nazwa wydania | Data |
|---|---|
| ZB-105403 | 19 lip 2022 |
Obiekty
Podobne
Pieszczek, Barbara
Jamróz, Witold
Antosik-Rogóż, Agata
Niwiński, Krzysztof
