Object

Title: Evaluation of the selected immunological parameters and fibrosing factors in atrophoderma Pasini-Pierini and morphea en plaques

Abstract:

Despite significant differences m the clinical picture morphea en plaques (MP) and atrophoderma Pasini-Pierini (APP) are regarded as particular types of localized scleroderma. The aim of this study was to determine similarities and/or differences between MP and APP. Following methods are used in the study: ELFA, ELISA, immunofluorescent, radioimmunologic and immunohistochemical examination. Vertebral column changes were found to be more frequent in the group of patients with MP. Antinuclear antibodies and antibodies against Borrelia burgdorferi were found more often among patients with APP. We also found correlation between level of PIIINP in supernatans and duration of the disease in patients with MP. In our study we observed different level of PIIINP and PINP in the serum and in the supernatant among patients with MP, APP and control. 80% of changed skin biopsies obtained from patients with APP showed low or high expression of collagen type I, in 71.4% of patients with MP we found high and very high expression of collagen type I. In 73.33 % of patients with APP, expression of collagen type III was low but in the MP group 35.71 % of patients showed high, and 14.29% showed very high collagen type III expression. More frequently high and very high expression of collagen type I and III coexisted with presence of active changes in patients with MP. Statistically significant was th ; e difference in number of mastocytes present in control group, compared with number of mastocytes in each of the individual groups of patients. Statistically relevant correlation between the duration of disease, and the number of mastocytes and between the degree of collagen type I and III expression, and the number of mastocytes was found in the group of patients with MP.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

dermatologia

Degree grantor:

Wydział Lekarski

Promoter:

Wojas-Pelc, Anna

Date issued:

2006

Identifier:

oai:dl.cm-uj.krakow.pl:1111

Call number:

ZB-105392

Language:

pol

Access rights:

nieograniczony

Object collections:

Last modified:

Jun 26, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

36

Number of object content views in PDF format

25

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1111

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-105392 Jun 26, 2023
×

Citation

Citation style:

This page uses 'cookies'. More information