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This publication is protected and can be accessed only from certain IPs.

Title: The influence of vitamins E and C supplementation on oxidative stress and plasma antioxidant potential parameters in men with atherosclerosis risk factors

Abstract:

The aim of the study was to evaluatethe influence of2-weeks, combined supplementation with vitamin E (2x100 IU/day) and vitamin C (2x200 mg/day) on oxidative stress and plasma antioxidant potential, m three groups of men: I healthy (n=23), II with (>2) atherosclerosis risk factors (n=39) III peripheral vascular disease patients (n=5O). The study had crossover design and includes two periods with vitamins supplementation: on empty stomach or with meals, each proceeded with "wash out period". Vitamin E and C, SH, albumin levels, FRAP, lag phase and TBARS, LOOH concentrations, AUC LDL oxidation were measured. The hsCRP test and the ACB test (assessing ischemia modified albumin (IMA) level) were also performed. Results: 1) Supplementation decreased oxidative stress and increased plasma antioxidant potential in all investigated groups, especially m II and III groups 2) Food intake increased the bioavailability of ingested vitamins E plus C and improved biochemical markers of plasma redox status 3) Subjects more responsive to vitamin E plus C supplementation were characterized by low initial vitamin E and vitamin C serum concentrations and high hsCRP and IMA concentrations, accompanied by undergoing modifications atherosclerosis risk factors: visceral obesity, hypertension and hypertriglicerydemia. Conclusion: The new risk factors: antioxidants, hsCRP and IMA ; levels allows for the early and more accurate assessment of risk of atherosclerosis. That may be useful m clinical practice m motivating patients to improve lifestyle and, if it is insufficient, also to vitamin E plus C supplementation.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia ; biochemia

Degree grantor:

Wydział Lekarski

Promoter:

Dembińska-Kieć, Aldona

Date issued:

2006

Identifier:

oai:dl.cm-uj.krakow.pl:1107

Call number:

ZB-105388

Language:

pol

Access rights:

tylko w bibliotece

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Last modified:

Jul 19, 2022

In our library since:

Nov 21, 2012

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http://dl.cm-uj.krakow.pl:8080/publication/1107

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ZB-105388 Jul 19, 2022
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