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Title: Influence of anti-inflammatory therapy on endothelial function in unstable angina


Background Endothelial inflammatory activation is associated with profound impairment in vasodilator endothelial function. The aim of the study was to analyze the impact of short-term anti-inflammatory therapy with high dose statin and cycklooxygenase-2 (COX-2) inhibitor on endothelial function in patients with non ST segment elevation Acute Coronary Syndromes - NSTE ACS. Methods In 30 pts with NSTE ACS and elevated C reactive protein level endothelial function was assessed by coronary Acetylcholine (Ach) test within non-culprit vessel. Quantitative coronary angiography was done at baseline and after maximum dose of Ach. Vessel response was calculated as a percent change of mean lumen diameter (% change of Mean Lumen Diameter (LD)). Then pts were randomized to three groups: A (n=11) placebo, B (n=11) 80 mg atorvastatin, C (n=8) 80 mg atorvastatin and 25 mg rofecoxib. After 7 days of therapy control test was done within the same indicatory segments. Recovery of endothelial function was calculated as difference (delta) in % changes of Mean LD between day 1 and day 7. Results At day 1 significant decrease in Mean LD between baseline and the highest dose of Ach was observed in all groups: -20 % (group A), -25 % (B) and -26 % (C). After 7 days of therapy these changes averaged -21 % (A), -15 % (B) and -10 % (C). Differences between day 1 and day 7 were -1% (A), +10 % (B), +16 % in C ; . Significant improvement of endothelial function was observed in group C. Conclusions NSTE ACS is associated with profound endothelial dysfunction. Short term therapy with 80 mg of atorvastatin and COX-2 inhibitor significantly improved endothelial function.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski


Dubiel, Jacek

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tylko w bibliotece

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Last modified:

Jul 19, 2022

In our library since:

Nov 21, 2012

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Edition name Date
ZB-105377 Jul 19, 2022


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