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Title: Relationship between selected polymorphisms of gene encoding p22phox subunit of the NADPH oxidase and endothelial function in patients with type 2 diabetes


Recent studies have identified genetic variability of p22phox NAD(P)H oxidase subunit (encoded by the CYBA gene), which is crucial to enzyme activity The present study aimed to evaluate the relationships between the incidence of C242T and A-930G gene polymorphism with endothelial function, atherosclerosis and levels of certain endothelial function markers in type 2 diabetics. 182 patients with type 2 diabetes were studied. Intima-media thickness (IMT) complex and flow mediated dilatation (FMD), NMD and plasma levels of von Willebrand factor (vWF) and malondialdehyde (MDA) were determined in relation to coding sequence (C242T) and promoter (A-930G) polymorphisms of CYBA. Polymorphism and allele distribution observed among Polish population of diabetics was similar to other Caucasian populations. No linkage disequilibrium was found between the two analyzed polymorphisms. C242T but not A-930G polymorphism was associated with endothelial function. This relationship was observed in patients with diabetes that lasted <10 years; with at least one microangiopathic complication; with coronary artery disease and increased cardiovascular risk. No relationship was found with IMT, MDA, vW in incidence of specific genotypes and allels with either investigated polymorphisms. The polymorphism C242T, of the coding sequence, but not of the promoter of p22phox gene encoding a key subunit of the N ; AD(P)H oxidase shows significant correlation with endothelial function in patients with type 2 diabetes. It seems thus that it might be a useful marker of the risk of endothelial dysfunction in type 2diabetic patients.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

endokrynologia ; genetyka

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Uniwersytet Jagielloński – Collegium Medicum


Guzik, Tomasz

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tylko w bibliotece

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Last modified:

Jan 30, 2023

In our library since:

Nov 21, 2012

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Edition name Date
ZB-105332 Jan 30, 2023


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