Advanced search ?

Object

Access Limited

This publication is protected and available only for logged users.
This publication is protected and available only for logged users.

Title: Relationship between selected polymorphisms of gene encoding p22phox subunit of the NADPH oxidase and endothelial function in patients with type 2 diabetes

Author:

Osmenda, Grzegorz

Date:

2007

Type:

Praca doktorska

Abstract:

Recent studies have identified genetic variability of p22phox NAD(P)H oxidase subunit (encoded by the CYBA gene), which is crucial to enzyme activity The present study aimed to evaluate the relationships between the incidence of C242T and A-930G gene polymorphism with endothelial function, atherosclerosis and levels of certain endothelial function markers in type 2 diabetics. 182 patients with type 2 diabetes were studied. Intima-media thickness (IMT) complex and flow mediated dilatation (FMD), NMD and plasma levels of von Willebrand factor (vWF) and malondialdehyde (MDA) were determined in relation to coding sequence (C242T) and promoter (A-930G) polymorphisms of CYBA. Polymorphism and allele distribution observed among Polish population of diabetics was similar to other Caucasian populations. No linkage disequilibrium was found between the two analyzed polymorphisms. C242T but not A-930G polymorphism was associated with endothelial function. This relationship was observed in patients with diabetes that lasted <10 years; with at least one microangiopathic complication; with coronary artery disease and increased cardiovascular risk. No relationship was found with IMT, MDA, vW in incidence of specific genotypes and allels with either investigated polymorphisms. The polymorphism C242T, of the coding sequence, but not of the promoter of p22phox gene encoding a key subunit of the NAD(P)H oxidase shows significant correlation with endothelial function in patients with type 2 diabetes. It seems thus that it might be a useful marker of the risk of endothelial dysfunction in type 2diabetic patients.

Level of degree:

2 - studia doktoranckie

Degree discipline:

endokrynologia ; genetyka

Degree grantor:

Wydział Lekarski

Promoter:

Tomasz Guzik

Date issued:

2006

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:1094

Call number:

ZB-105332

ControlNumberVIRTUA:

click here to follow the link

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Subject and keywords:

polymorphism CYBA NAD(P)H oxidase FMD diabetes mellitus

Object collections:

Last modified:

Feb 12, 2020

In our library since:

Nov 21, 2012

Number of object content hits:

12

Number of object content views in PDF format

12

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1094

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-105332 Feb 12, 2020

Objects

Similar

Relationship between selected polymorphisms of gene encoding p22phox subunit of the NADPH oxidase and endothelial function in patients with type 2 diabetes

Osmenda, Grzegorz

2007
Praca doktorska

Experimental evaluation of endothelial function in spontaneous hypertension

Jopek, Andrzej

2007
Praca doktorska

Role of superoxide in the pathogenesis of abdominal aortic aneurysms

Guzik, Bartłomiej

2006
Praca doktorska

Endothelial function in atrial fibrillation

Rewiuk, Krzysztof.

2014
Praca doktorska

The role of endothelium and disturbances of blood flowautoregulationin the pathogenesis of reflex syncope

Wnuk, Mateusz

2012
Praca doktorska

Endothelial dysfunction in systemie connective tissue diseases

Pacholczak-Madej, Renata

2019
Praca doktorska

Effect of fenofibrate therapy on brachial artery diastolic response, and plasma N1-methylnicotinamide, and homocysteine concentrations in the subjects with dyslipidemia

Kotula-Horowitz, Katarzyna

2020
Praca doktorska

Insulin resistance candidate gene polymorphisms and predisposition to Type 2 diabetes mellitus

Wanic, Krzysztof

2005
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information