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Title: Effectiveness of Helicobacter pylori eradication treatment taking in to account its resistance to antibiotics


The discovery of Helicobacter pylori (Hp) provided a possibility to cure effectively patients with peptic ulcers. Recent studies have shown varying sensitivity of Hp strains to antibiotics and an increasing resistance to some of the recommended drugs. The purpose of the present thesis was to evaluate the efficacy of the currently recommended eradication schemes and to study the increasing resistance of Hp strains to recommended antibiotics. Furthermore I analyzed the effect of Lacidofil on the efficacy of first-line treatment with amoxiciline and clarithromycin. The study population consisted of 641 patients: 192 received amoxiciline with clarithromycin and PPI, 241 tetracycline, tinidazole, bismuth and PPI, 53 amoxiciline with clarithromycin and PPI supplemented with Lacidofil. The efficacy of eradication treatment was evaluated by the 13C urease breath test. The microbiological examination included 111 samples of Hp. The present study demonstrated low efficacy of the tetracycline, tinidazole, bismuth and PPI scheme i.e. 71.4%, moderate efficacy of the amoxiciline with clarithromycin and PPI scheme i.e. 85.9% whereas the supplementation with Lacidofil significantly increased the efficacy of eradication to 94.3%. The microbiological examination revealed a relatively high level of primary resistance to clarithromycin (22.2%) and a high level to metronidazole (46.7%), with no res ; istance to amoxiciline. However, the most important finding is the high level of secondary resistance to clarithromycin and metronidazole (more than 66% in both cases). The present findings suggest that the need for modification of the recommended eradication schemes.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu trawiennego ; mikrobiologia

Degree grantor:

Wydział Lekarski


Konturek, Stanisław

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tylko w bibliotece

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Last modified:

Jul 18, 2022

In our library since:

Nov 21, 2012

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Edition name Date
ZB-105326 Jul 18, 2022


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