The aim of the study was to evaluate the efficacy of Palliative therapy provided to patients staying at home, in hospice or in a hospital respectively. The study involved 151 end-stage patients. The following methods were used in the study: the Rotterdam Symptom Checklist with Quality of Life and Karnofsky’ego Performance Status Assessment, The Support Team Assessment Schedule, Spirituality Questionnaire and Care Satisfaction Questionnaire. Treatment efficacy assessment was performed three times, at 8 to 10 day intervals. Based on the results obtained, patients dying at their homes were found to have the highest quality of life, the best control of both somatic and mental symptoms and the highest level of satisfaction from received care. The poorest treatment results were obtained in the hospital group, where the patients reported various somatic and mental ailments, presented poor quality of life and the lowest level of satisfaction from received care. An important conclusion is that all the patients irrespective of the place where palliative care was provided and had effective pain control. Mental suffering was perceived as the most severe by the hospitalised patients. Social pain was predominated in the hospice and the hospital groups. On the contrary, patient’s sense of life and experience of love decreased spiritual and existential suffering.