Obiekt
Tytuł: Microspheres as multicompartment systems for ocular use
Abstrakt:
The aim of the study was to assess the possibility of using AQOAT® and chitosan as carriers of piroxicam and prednisolone administered to the eye in order to enhance their pharmaceutical availability. The assumption of the study was to make microspheres by the spray drying method and minitablets by direct compression. Results of scanning and polarizing microscope analyses, X-ray diffractions and DSC revealed the influence of the quantity and the type of the carrier on the drugs as well as prepared microspheres. Considering the shape and size it was shown that the best microspheres were obtained while using the drug and AQOAT® (1:1) and (1:2). Ternary microspheres additionally containing Carbopol 940 tend to have larger molecule diameter than binary ones as well as irregular shape. The gradual release of piroxicam was obtained from piroxicam - AQOA T® AS-LF (1: 1) microspheres in the examinations of the profiles of the drug release from microspheres. The introduction of Carbopol 940 to the binary systems caused a sustain of the drug re lease. Minitablets containing piroxicam and AQOA T® AS-LF (1 :3) were assessed as the best ones due to the drug release profile. After 8 hours the quantity of the released drug was approximately two-fold larger when compared with minitablets only with the drug. Examinations of the release rate revealed the influence of the examin ; ation method on the profile of the drug release from minitablets. Sterilizing microspheres and minitablets with ionizing radiation ensured that the sterilized formulation was obtained and then confirmed by microbiological examinations.
Miejsce wydania:
Stopień studiów:
Dyscyplina:
Instytucja nadająca tytuł:
Promotor:
Data wydania:
Identyfikator:
Sygnatura:
Język:
Prawa dostępu:
Kolekcje, do których przypisany jest obiekt:
Data ostatniej modyfikacji:
21 lip 2022
Data dodania obiektu:
21 lis 2012
Liczba wyświetleń treści obiektu:
2
Liczba wyświetleń treści obiektu w formacie PDF
0
Wszystkie dostępne wersje tego obiektu:
http://dl.cm-uj.krakow.pl:8080/publication/1050
Wyświetl opis w formacie RDF:
Wyświetl opis w formacie OAI-PMH:
| Nazwa wydania | Data |
|---|---|
| ZB-108272 | 21 lip 2022 |
Obiekty
Podobne
Antosik-Rogóż, Agata
