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Title: The link between adiponectin gene polymorphisms and selected metabolic syndrome phenotypes

Author:

Szopa, Magdalena

Date:

2008

Type:

Praca doktorska

Abstract:

Background: Adiponectin, a protein secreted by adipose tissue but present at low levels in obesity, is now widely recognized as a key determinant of insulin sensitivity and of protection against obesity-associated metabolic syndrome. The adiponectin gene is very polymorphic and several of its variants contribute to adiponectin level, function and are associated with metabolic syndrome phenotypes. The results differ ethnically. Aim: To investigate associations of three single nucleotide polymorphisms (SNPs) 45T>G, 276G>T, -11391G>A of the adiponectin gene and metabolic syndrome phenotypes in the population of South of Poland. Methods: 100 non-diabetic subjects were selected according to the ATP III definition. To estimate the link between type 2 diabetes (DM2), 550 DM2 patients and 494 controls were included. The anthropometric measurements (weight, height, waist and hip circumference) and level of biochemical parameters including fasting adiponectin, leptin, insulin, glucose, cholesterol, triglyceride, free fatty acids and von Willebrand factor were assessed. Two types of Oral Lipid Tolerance Tests (OLTT) were included. The SNPs of the adiponectin gene were determined by PCR-based assay for the analysis of restriction fragment length polymorphism. New indices of insulin resistance such as leptin/adiponectin ratio (L/A), HOMA-AD were calculated. Statistical analyses were performed using SAS, version 9.1. Results: All three genotypes were in compliance with Hardy-Weinberg equilibrium. The frequency of T allele at position 276 among non-diabetic (20%) versus DM2 (15%) subjects was significantly higher. The T allele was significantly associated(p<0,05) with lower insulin resistance (HOMA-IR, fasting insulin) among non-diabetic subjects. T allele carriers among DM2 subjects rarely suffered from hypertension (p<0,005). An allele at position -11391 was significantly associated (p<0,05) with higher insulin resistance (HOMA-IR, fasting insulin) and an higher LDL level. L/A ratio and fasting insulin were higher among carriers of the G allele at position 45 (p<0,05). The OLTT revealed higher postprandial insulin levels in G allele carriers at position 45 (p<0,05). Adjustments for gender, BMI and age were included in every analysis. Comparing the results with haplotype analysis the effect of SNPs was confirmed. Conclusions: This study demonstrates the link between metabolic syndrome phenotypes and adiponectin polymorphisms: 45T>G, 276G>T, -11391G>A in the population of the South of Poland. Allele G at position 276, allele A at position -11391 and allele T at position 45 seem to be markers of the risk of metabolic syndrome.

Level of degree:

2 - studia doktoranckie

Degree discipline:

endokrynologia ; genetyka

Degree grantor:

Wydział Lekarski

Promoter:

Aldona Dembińska-Kieć

Date issued:

2007

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:1042

Call number:

ZB-108005

ControlNumberVIRTUA:

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Subject and keywords:

adiponectin polymorphism metabolic syndrome

Object collections:

Last modified:

Aug 19, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

1

Number of object content views in PDF format

1

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1042

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Edition name Date
ZB-108005 Aug 19, 2019

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