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Borratyńska, Anna
2008
Praca doktorska
Based on data from family studies the concept of genetic susceptibility for aneurysmal SAH is increasingly supported.The aim of the study was to determine whether the polymorphisms of MMP-2 (–1575 G/A, –1306 C/T, –790 T/G i –735 C/T) and MMP-9 (–1562 C/T, 279 R/Q, 574 R/P i 668 Q/R) influence the risk for SAH. A total of 241 SAH patients and 241 subjects from the general population were studied. MMP-2 and MMP-9 genotypes were determined by PCR and RFLP methods. Data concerning demographics and risk factors for SAH were collected. The study showed that AA (–1575 G/A polymorphism), TT (–1306 C/T polymorphism) and GG genotypes (–790 T/G polymorphism) of the MMP-2 gene are independent risk-reducing factors for SAH. The haplotype A-1575T-1306G-790 was less frequent in SAH patients and the haplotype G-1575C-1306T-790 more frequent in SAH patients as compared to the control group. No significant associations were observed between the studied MMP-9 polymorphisms and SAH. The study showed that hypertension, current cigarette smoking, and excessive alcohol intake are important modifiable risk factors for SAH. Whereas, hypercholesterolemia and higher BMI are independent risk-reducing factors for SAH. Further studies are needed to define the significance of MMP-2 and MMP-9 genes polymorphisms in SAH. Determination of genetic markers may be fundamental for effective prevention strategies.
Kraków
2 - studia doktoranckie
neurologia
Wydział Lekarski
Szczudlik, Andrzej
oai:dl.cm-uj.krakow.pl:1029
ZB-107987
pol
tylko w bibliotece
Aug 11, 2022
Nov 21, 2012
15
0
http://dl.cm-uj.krakow.pl:8080/publication/1029
RDF
OAI-PMH
Dyszkiewicz, Sławomir
Curyło, Małgorzata
Morga, Rafał
Grzywna, Ewelina
Lichołai, Sabina
Grzanka, Małgorzata
Szopa, Magdalena
Citation style: chicago-author-date iso690-author-date
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