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Title: Genetic polymorphisms for aneurysmal subarachnoid hemorrhage

Author:

Borratyńska, Anna

Date:

2008

Type:

Praca doktorska

Abstract:

Based on data from family studies the concept of genetic susceptibility for aneurysmal SAH is increasingly supported.The aim of the study was to determine whether the polymorphisms of MMP-2 (–1575 G/A, –1306 C/T, –790 T/G i –735 C/T) and MMP-9 (–1562 C/T, 279 R/Q, 574 R/P i 668 Q/R) influence the risk for SAH. A total of 241 SAH patients and 241 subjects from the general population were studied. MMP-2 and MMP-9 genotypes were determined by PCR and RFLP methods. Data concerning demographics and risk factors for SAH were collected. The study showed that AA (–1575 G/A polymorphism), TT (–1306 C/T polymorphism) and GG genotypes (–790 T/G polymorphism) of the MMP-2 gene are independent risk-reducing factors for SAH. The haplotype A-1575T-1306G-790 was less frequent in SAH patients and the haplotype G-1575C-1306T-790 more frequent in SAH patients as compared to the control group. No significant associations were observed between the studied MMP-9 polymorphisms and SAH. The study showed that hypertension, current cigarette smoking, and excessive alcohol intake are important modifiable risk factors for SAH. Whereas, hypercholesterolemia and higher BMI are independent risk-reducing factors for SAH. Further studies are needed to define the significance of MMP-2 and MMP-9 genes polymorphisms in SAH. Determination of genetic markers may be fundamental for effective prevention strategies.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

neurologia

Degree grantor:

Wydział Lekarski

Promoter:

Szczudlik, Andrzej

Date issued:

2008

Identifier:

oai:dl.cm-uj.krakow.pl:1029

Call number:

ZB-107987

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

polymorphism aneurysms matrix metalloproteinase subarachnoid hemorrhage

Object collections:

Last modified:

Aug 11, 2022

In our library since:

Nov 21, 2012

Number of object content hits:

15

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1029

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ZB-107987 Aug 11, 2022

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