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Title: Genetic polymorphisms for aneurysmal subarachnoid hemorrhage


Based on data from family studies the concept of genetic susceptibility for aneurysmal SAH is increasingly supported.The aim of the study was to determine whether the polymorphisms of MMP-2 (–1575 G/A, –1306 C/T, –790 T/G i –735 C/T) and MMP-9 (–1562 C/T, 279 R/Q, 574 R/P i 668 Q/R) influence the risk for SAH. A total of 241 SAH patients and 241 subjects from the general population were studied. MMP-2 and MMP-9 genotypes were determined by PCR and RFLP methods. Data concerning demographics and risk factors for SAH were collected. The study showed that AA (–1575 G/A polymorphism), TT (–1306 C/T polymorphism) and GG genotypes (–790 T/G polymorphism) of the MMP-2 gene are independent risk-reducing factors for SAH. The haplotype A-1575T-1306G-790 was less frequent in SAH patients and the haplotype G-1575C-1306T-790 more frequent in SAH patients as compared to the control group. No significant associations were observed between the studied MMP-9 polymorphisms and SAH. The study showed that hypertension, current cigarette smoking, and excessive alcohol intake are important modifiable risk factors for SAH. Whereas, hypercholesterolemia and higher BMI are independent risk-reducing factors for SAH. Further studies are needed to define the significance of MMP-2 and MMP-9 genes polymorphisms in SAH. Determination of genetic markers may be fundamental for effective prevention strategies.

Level of degree:

2 - studia doktoranckie

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Degree grantor:

Wydział Lekarski


Andrzej Szczudlik

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tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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Last modified:

Feb 12, 2020

In our library since:

Nov 21, 2012

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Edition name Date
ZB-107987 Feb 12, 2020


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