Title:

Factors influencing skin microcirculation in patients with heart failure

Author:

Dubiel, Marzena

Subject:

microcirculation ; heart failure ; Laser Doppler Flowmetry

Abstract:

Patients with heart failure have impaired peripheral blood flow. Hypothesis of the study was that in heart failure there was microcirculatory perfusion impairment both in basal conditions and under the stimuli of vasodilatation which was related to clinical progression of disease, left ventricle ejection fraction (EF), diastolic diameter (LVEDd), diastolic dysfunction and NT-proBNP level. 100 patients with heart failure were involved with the study. History, physical examination, anthropomorphic measurements, blood pressure, laboratory tests, levels of NT-proBNP, EKG, chest radiogram, echocardiography and microcirculation assessment using Laser Doppler Flowmetry were obtained with respect to every patent. The results of the study showed significant negative interrelation between LVEDd and mean flow in basal conditions (MFb) and in 44 dgr. Centigrade (MF44). Reduced EF was related to impairment in microcirculatory blood flow. Advanced diastolic dysfunction was also connected with peripheral flow reduction. Significant positive correlation was found between beta-blockers (BB) and MFb, ACEI and MFb, ACEI and MF44, acetylsalicylic acid and MF44. The analysis was then repeated excluding patients on carvedilol treatment. Results suggested that carvedilol may be responsible for the observed positive effect as other BB caused significant reduction in microcirculatory blood flow. The observed improvement in blood flow may be considered as an indicator of the possible reversal of microcirculatory impairment.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Tomasz Grodzicki

Date:

2008

Date issued:

2007

Type:

Praca doktorska

Format:

application/pdf

Call number:

ZB-107618

ControlNumberVIRTUA:

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Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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